Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response
Joint Authors
Zhu, Binnian
Dong, Jun
Gao, Xiangyun
He, Yanfei
Sun, Hongxiang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To investigate the antiasthmatic effects of Sanglong pingchuan decoction (SLPCD) and to explore its mechanisms of action.
Methods.
The serum, bronchoalveolar lavage fluid (BALF), and lung tissues from OVA-induced allergic asthma mice were collected 24 h after the last administration.
Lung pathological changes were observed by H&E staining.
The inflammatory cells in BALF were counted by flow cytometry.
The levels of total IgE in serum and cytokines in BALF were determined by ELISA.
The expression levels of cytokine mRNA in lung were assayed by qRT-PCR.
Results.
SLPCD significantly inhibited airway inflammation, reduced inflammatory cells in BALF, reduced the levels of total IgE in serum and Th2 cytokines (IL-10 and IL-13) in BALF, and downregulated the mRNA expression levels of Th2 cytokines (IL-4, IL-5, IL-10, and IL-13) in lung of asthmatic mice.
However, SLPCD remarkably elevated the level of Th1 cytokine IFN-γ in BALF and upregulated the mRNA expression levels of Th1 cytokines (IL-2 and IFN-γ) in lung of asthmatic mice.
Conclusion.
SLPCD could attenuate airway inflammation and alleviate the pathogenesis in asthma mice through inducing a balanced Th1/Th2 response and could act as an effective drug for treatment of asthma.
American Psychological Association (APA)
Zhu, Binnian& Dong, Jun& Gao, Xiangyun& He, Yanfei& Sun, Hongxiang. 2018. Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154642
Modern Language Association (MLA)
Zhu, Binnian…[et al.]. Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154642
American Medical Association (AMA)
Zhu, Binnian& Dong, Jun& Gao, Xiangyun& He, Yanfei& Sun, Hongxiang. Antiasthmatic Effects of Sanglong Pingchuan Decoction through Inducing a Balanced Th1Th2 Immune Response. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154642
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154642