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Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.
المؤلفون المشاركون
Zeng, Mengnan
Zhang, Beibei
Feng, Weisheng
Zheng, Xiaoke
Li, Meng
Zhang, Zhi-guang
Zhang, Jingke
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-04
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
There has been great interest in phytoestrogens, which are polyhydric compounds that are derived from plants and have a structure similar to that of the mammalian steroid hormone 17β-estradiol.
The present study examined the estrogenic effects of a new natural uridine derivative, lepidiumuridine A (LA), that was isolated from the seeds of Lepidium apetalum.
The structure was clarified and determined via analysis of extensive spectroscopic data interpretation.
The activity of LA was investigated by measuring the levels of estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), and the uterus growth in mice.
The proliferation experiment of MCF-7 breast cancer cells was also conducted.
Western blot, in-cell western, and antagonist assays with methyl piperidino-pyrazole (MPP) were used for exploring the mechanism of the effects of LA.
The results showed that LA elevated the uterine coefficient, the levels of E2, and FSH significantly.
In addition, LA significantly elevated ERα expression in the uterus and MCF-7 cells.
MPP inhibited the proliferation of LA-stimulated MCF-7 cell and ERα expression in MCF-7 cells.
Taken together, LA had an estrogen-like effect, which was mainly mediated by the estrogen receptor ERα.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Meng& Zeng, Mengnan& Zhang, Zhi-guang& Zhang, Beibei& Zhang, Jingke& Zheng, Xiaoke…[et al.]. 2018. Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Meng…[et al.]. Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1154681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Meng& Zeng, Mengnan& Zhang, Zhi-guang& Zhang, Beibei& Zhang, Jingke& Zheng, Xiaoke…[et al.]. Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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