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Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.
Joint Authors
Zeng, Mengnan
Zhang, Beibei
Feng, Weisheng
Zheng, Xiaoke
Li, Meng
Zhang, Zhi-guang
Zhang, Jingke
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
There has been great interest in phytoestrogens, which are polyhydric compounds that are derived from plants and have a structure similar to that of the mammalian steroid hormone 17β-estradiol.
The present study examined the estrogenic effects of a new natural uridine derivative, lepidiumuridine A (LA), that was isolated from the seeds of Lepidium apetalum.
The structure was clarified and determined via analysis of extensive spectroscopic data interpretation.
The activity of LA was investigated by measuring the levels of estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), and the uterus growth in mice.
The proliferation experiment of MCF-7 breast cancer cells was also conducted.
Western blot, in-cell western, and antagonist assays with methyl piperidino-pyrazole (MPP) were used for exploring the mechanism of the effects of LA.
The results showed that LA elevated the uterine coefficient, the levels of E2, and FSH significantly.
In addition, LA significantly elevated ERα expression in the uterus and MCF-7 cells.
MPP inhibited the proliferation of LA-stimulated MCF-7 cell and ERα expression in MCF-7 cells.
Taken together, LA had an estrogen-like effect, which was mainly mediated by the estrogen receptor ERα.
American Psychological Association (APA)
Li, Meng& Zeng, Mengnan& Zhang, Zhi-guang& Zhang, Beibei& Zhang, Jingke& Zheng, Xiaoke…[et al.]. 2018. Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154681
Modern Language Association (MLA)
Li, Meng…[et al.]. Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1154681
American Medical Association (AMA)
Li, Meng& Zeng, Mengnan& Zhang, Zhi-guang& Zhang, Beibei& Zhang, Jingke& Zheng, Xiaoke…[et al.]. Lepidiumuridine A: A New Natural Uridine Derivative as a Phytoestrogen Isolated from the Seeds of Lepidium apetalum Willd.. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1154681
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154681