Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion
المؤلفون المشاركون
Cruz, Maria Teresa
Santos, Telmo N.
Costa, Gustavo
Ferreira, J. Pinto
Liberal, Joana
Francisco, Vera
Paranhos, António
Castelo-Branco, M.
Figueiredo, I. Vitória
Batista, M. Teresa
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Agrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases.
Therefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI).
Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MSn.
To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used.
In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production.
In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model.
Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities.
The safety profile was disclosed in vitro and in vivo, using MTT and hematoxylin assays, respectively.
Vitexin, quercetin O-galloyl-hexoside, and kaempferol O-acetyl-hexosyl-rhamnoside were referred to in this species for the first time.
AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals.
Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI.
In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity.
Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santos, Telmo N.& Costa, Gustavo& Ferreira, J. Pinto& Liberal, Joana& Francisco, Vera& Paranhos, António…[et al.]. 2017. Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154711
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santos, Telmo N.…[et al.]. Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154711
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santos, Telmo N.& Costa, Gustavo& Ferreira, J. Pinto& Liberal, Joana& Francisco, Vera& Paranhos, António…[et al.]. Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154711
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154711
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر