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Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion
Joint Authors
Cruz, Maria Teresa
Santos, Telmo N.
Costa, Gustavo
Ferreira, J. Pinto
Liberal, Joana
Francisco, Vera
Paranhos, António
Castelo-Branco, M.
Figueiredo, I. Vitória
Batista, M. Teresa
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Agrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases.
Therefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI).
Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MSn.
To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used.
In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production.
In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model.
Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities.
The safety profile was disclosed in vitro and in vivo, using MTT and hematoxylin assays, respectively.
Vitexin, quercetin O-galloyl-hexoside, and kaempferol O-acetyl-hexosyl-rhamnoside were referred to in this species for the first time.
AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals.
Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI.
In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity.
Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols.
American Psychological Association (APA)
Santos, Telmo N.& Costa, Gustavo& Ferreira, J. Pinto& Liberal, Joana& Francisco, Vera& Paranhos, António…[et al.]. 2017. Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154711
Modern Language Association (MLA)
Santos, Telmo N.…[et al.]. Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154711
American Medical Association (AMA)
Santos, Telmo N.& Costa, Gustavo& Ferreira, J. Pinto& Liberal, Joana& Francisco, Vera& Paranhos, António…[et al.]. Antioxidant, Anti-Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154711