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Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes
المؤلفون المشاركون
Chang, Tsong-Min
Tsen, Jen-Horng
Yen, Hsuan
Yang, Ting-Ya
Huang, Huey-Chun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Periostracum cicadae is widely used for the treatment of skin diseases such as eczema, pruritus, and itching.
The current study sought to evaluate the effect of P.
cicadae extract on ultraviolet B (UVB) irradiation and identify the mechanisms involved.
Photodamage-protective activity of P.
cicadae extracts against oxidative challenge was screened using HaCaT keratinocytes.
P.
cicadae extracts did not affect cell viability but decreased reactive oxygen species (ROS) production.
The extract attenuates the expression of interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), and MMP-9 in UVB-treated HaCaT cells.
Also, P.
cicadae abrogated UVB-induced activation of NF-κB, p53, and activator protein-1 (AP-1).
The downmodulation of IL-6 by P.
cicadae was inhibited by the p38 inhibitor (SB203580) or JNK inhibitor (SP600125).
Moreover, the extract attenuated the expression of NF-κB and induced thrombomodulin in keratinocytes and thereby effectively downregulated inflammatory responses in the skin.
The nuclear accumulation and expression of NF-E2-related factor (Nrf2) were increased by P.
cicadae treatment.
Furthermore, treatment with P.
cicadae remarkably ameliorated the skin’s structural damage induced by irradiation.
This study demonstrates that P.
cicadae may protect skin cells against oxidative insult by modulating ROS concentration, IL-6, MMPs generation, antioxidant enzymes activity, and cell signaling pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Tsong-Min& Tsen, Jen-Horng& Yen, Hsuan& Yang, Ting-Ya& Huang, Huey-Chun. 2017. Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154724
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Tsong-Min…[et al.]. Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154724
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Tsong-Min& Tsen, Jen-Horng& Yen, Hsuan& Yang, Ting-Ya& Huang, Huey-Chun. Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154724
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154724
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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