Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes
Joint Authors
Chang, Tsong-Min
Tsen, Jen-Horng
Yen, Hsuan
Yang, Ting-Ya
Huang, Huey-Chun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Periostracum cicadae is widely used for the treatment of skin diseases such as eczema, pruritus, and itching.
The current study sought to evaluate the effect of P.
cicadae extract on ultraviolet B (UVB) irradiation and identify the mechanisms involved.
Photodamage-protective activity of P.
cicadae extracts against oxidative challenge was screened using HaCaT keratinocytes.
P.
cicadae extracts did not affect cell viability but decreased reactive oxygen species (ROS) production.
The extract attenuates the expression of interleukin-6 (IL-6), matrix metalloproteinase-2 (MMP-2), and MMP-9 in UVB-treated HaCaT cells.
Also, P.
cicadae abrogated UVB-induced activation of NF-κB, p53, and activator protein-1 (AP-1).
The downmodulation of IL-6 by P.
cicadae was inhibited by the p38 inhibitor (SB203580) or JNK inhibitor (SP600125).
Moreover, the extract attenuated the expression of NF-κB and induced thrombomodulin in keratinocytes and thereby effectively downregulated inflammatory responses in the skin.
The nuclear accumulation and expression of NF-E2-related factor (Nrf2) were increased by P.
cicadae treatment.
Furthermore, treatment with P.
cicadae remarkably ameliorated the skin’s structural damage induced by irradiation.
This study demonstrates that P.
cicadae may protect skin cells against oxidative insult by modulating ROS concentration, IL-6, MMPs generation, antioxidant enzymes activity, and cell signaling pathways.
American Psychological Association (APA)
Chang, Tsong-Min& Tsen, Jen-Horng& Yen, Hsuan& Yang, Ting-Ya& Huang, Huey-Chun. 2017. Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154724
Modern Language Association (MLA)
Chang, Tsong-Min…[et al.]. Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1154724
American Medical Association (AMA)
Chang, Tsong-Min& Tsen, Jen-Horng& Yen, Hsuan& Yang, Ting-Ya& Huang, Huey-Chun. Extract from Periostracum cicadae Inhibits Oxidative Stress and Inflammation Induced by Ultraviolet B Irradiation on HaCaT Keratinocytes. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1154724
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154724