In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa
المؤلفون المشاركون
Berdja, Sihem
Aouichat Bouguerra, Souhila
Bensiameur-Touati, Karima
Kacimi, Ghouti
Haffaf, El-Mehdi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Context.
Nigella sativa seeds are usually used as traditional medicine for a wide range of therapeutic purposes.
Objective.
To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect.
Methods.
5 AqE.NS doses (2, 6.4, 21, 33, and 60 g/Kg) were daily administered to mice by gavage.
Biochemical parameters measurements and histological study of the liver and the kidney were performed after 6 weeks of supplementation.
Thereafter, and after inducing diabetes by alloxan, rats were treated by 2 g/Kg of AqE.NS during 8 weeks.
Metabolic parameters were measured on sera.
A horizontal electrophoresis of plasmatic lipoprotein was conducted.
Glycogen, total lipids, and triglycerides were measured in the liver.
TBARS were evaluated on adipose tissue, liver, and pancreas.
Results.
AqE.NS showed no variation in urea and albumin at the 5 doses, but hepatotoxicity from 21 g/Kg was confirmed by histopathological observations of the liver.
In diabetic rats, AqE.NS significantly decreased glycemia, TG, T-cholesterol, LDL-c, and TBARS and showed a restored insulinemia and a significant increase in HDL-c.
Results on the liver indicated a decrease in lipids and a possible glycogenogenesis.
Conclusion.
AqE.NS showed its safety at low doses and its evident antihyperglycemic, antihyperlipidemic, and antioxidant effect.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bensiameur-Touati, Karima& Kacimi, Ghouti& Haffaf, El-Mehdi& Berdja, Sihem& Aouichat Bouguerra, Souhila. 2017. In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154757
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bensiameur-Touati, Karima…[et al.]. In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154757
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bensiameur-Touati, Karima& Kacimi, Ghouti& Haffaf, El-Mehdi& Berdja, Sihem& Aouichat Bouguerra, Souhila. In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154757
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154757
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر