In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa
Joint Authors
Berdja, Sihem
Aouichat Bouguerra, Souhila
Bensiameur-Touati, Karima
Kacimi, Ghouti
Haffaf, El-Mehdi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-12
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Context.
Nigella sativa seeds are usually used as traditional medicine for a wide range of therapeutic purposes.
Objective.
To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect.
Methods.
5 AqE.NS doses (2, 6.4, 21, 33, and 60 g/Kg) were daily administered to mice by gavage.
Biochemical parameters measurements and histological study of the liver and the kidney were performed after 6 weeks of supplementation.
Thereafter, and after inducing diabetes by alloxan, rats were treated by 2 g/Kg of AqE.NS during 8 weeks.
Metabolic parameters were measured on sera.
A horizontal electrophoresis of plasmatic lipoprotein was conducted.
Glycogen, total lipids, and triglycerides were measured in the liver.
TBARS were evaluated on adipose tissue, liver, and pancreas.
Results.
AqE.NS showed no variation in urea and albumin at the 5 doses, but hepatotoxicity from 21 g/Kg was confirmed by histopathological observations of the liver.
In diabetic rats, AqE.NS significantly decreased glycemia, TG, T-cholesterol, LDL-c, and TBARS and showed a restored insulinemia and a significant increase in HDL-c.
Results on the liver indicated a decrease in lipids and a possible glycogenogenesis.
Conclusion.
AqE.NS showed its safety at low doses and its evident antihyperglycemic, antihyperlipidemic, and antioxidant effect.
American Psychological Association (APA)
Bensiameur-Touati, Karima& Kacimi, Ghouti& Haffaf, El-Mehdi& Berdja, Sihem& Aouichat Bouguerra, Souhila. 2017. In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154757
Modern Language Association (MLA)
Bensiameur-Touati, Karima…[et al.]. In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1154757
American Medical Association (AMA)
Bensiameur-Touati, Karima& Kacimi, Ghouti& Haffaf, El-Mehdi& Berdja, Sihem& Aouichat Bouguerra, Souhila. In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1154757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154757