Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity
المؤلفون المشاركون
Li, Hao
Ma, Lina
Chen, Shangke
Li, Shaochun
Deng, Lijuan
Li, Yikui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester, diallyl thiosulfinate) is the main biologically active ingredient in garlic.
The present study investigated the protective effect of allicin against cardiomyocyte apoptosis that was induced by ischemia in vitro and the potential molecular mechanisms that were involved in this antiapoptotic effect.
The results indicated that allicin increased H9c2 cell activity and attenuated the rate of apoptosis that was induced by ischemia/hypoxia.
Intracellular calcium concentrations significantly decreased in the allicin-treated groups.
Bax expression significantly decreased, and Bcl-2 expression increased in allicin-treated rats.
Nitric oxide blockade significantly inhibited these effects.
Allicin also increased the activity of SOD and NO release and decreased MDA levels.
Allicin significantly increased the expression of eNOS, Nrf2, and HO-1 proteins.
Collectively, these findings demonstrate that allicin protects H9c2 cells against apoptosis, and this protective effect appears to occur via eNOS/NO pathway-mediated antioxidant activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ma, Lina& Chen, Shangke& Li, Shaochun& Deng, Lijuan& Li, Yikui& Li, Hao. 2018. Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154800
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ma, Lina…[et al.]. Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154800
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ma, Lina& Chen, Shangke& Li, Shaochun& Deng, Lijuan& Li, Yikui& Li, Hao. Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154800
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154800
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر