Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity
Joint Authors
Li, Hao
Ma, Lina
Chen, Shangke
Li, Shaochun
Deng, Lijuan
Li, Yikui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester, diallyl thiosulfinate) is the main biologically active ingredient in garlic.
The present study investigated the protective effect of allicin against cardiomyocyte apoptosis that was induced by ischemia in vitro and the potential molecular mechanisms that were involved in this antiapoptotic effect.
The results indicated that allicin increased H9c2 cell activity and attenuated the rate of apoptosis that was induced by ischemia/hypoxia.
Intracellular calcium concentrations significantly decreased in the allicin-treated groups.
Bax expression significantly decreased, and Bcl-2 expression increased in allicin-treated rats.
Nitric oxide blockade significantly inhibited these effects.
Allicin also increased the activity of SOD and NO release and decreased MDA levels.
Allicin significantly increased the expression of eNOS, Nrf2, and HO-1 proteins.
Collectively, these findings demonstrate that allicin protects H9c2 cells against apoptosis, and this protective effect appears to occur via eNOS/NO pathway-mediated antioxidant activity.
American Psychological Association (APA)
Ma, Lina& Chen, Shangke& Li, Shaochun& Deng, Lijuan& Li, Yikui& Li, Hao. 2018. Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154800
Modern Language Association (MLA)
Ma, Lina…[et al.]. Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154800
American Medical Association (AMA)
Ma, Lina& Chen, Shangke& Li, Shaochun& Deng, Lijuan& Li, Yikui& Li, Hao. Effect of Allicin against IschemiaHypoxia-Induced H9c2 Myoblast Apoptosis via eNOSNO Pathway-Mediated Antioxidant Activity. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154800