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The Synergy and Mode of Action of Cyperus rotundus L. Extract Plus Ampicillin against Ampicillin-Resistant Staphylococcus aureus
المؤلفون المشاركون
Eumkeb, Griangsak
Cheypratub, Prairadda
Leeanansaksiri, Wilairat
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Cyperus rotundus L.
has been used for pharmaceutical applications including antibacterial infections.
Nevertheless, there is still no data regarding the mode of actions.
This study aimed to determine the antibacterial activity and mode of actions of Cyperus rotundus extract (CRE) against ampicillin-resistant Staphylococcus aureus (ARSA) which poses a serious problem for hospitalized patients.
The majority of chemical compounds of CRE were flavonoids and alkaloids.
The minimum inhibitory concentrations (MICs) for ampicillin and CRE against all ARSA strains were 64 μg/ml and 0.5 mg/ml, respectively.
Checkerboard assay revealed synergistic activity in the combination of ampicillin and CRE at the lowest fractional inhibitory concentration index (FICI) at 0.27.
The killing curve assay had confirmed the synergistic and bactericidal activity of the combination against ARSA.
Electron microscopic results showed that these ARSA cells treated with this combination caused peptidoglycan and cytoplasmic membrane (CM) damage and average cell areas significantly smaller than control.
Also, this combination caused an increase in CM permeability of ARSA.
CRE revealed the inhibitory activity against β-lactamase.
It is normally known that some drugs are derived from flavonoids or alkaloids.
So, this CRE proposes the potential to develop a novel adjunct phytopharmaceutical to ampicillin for the remedy of ARSA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheypratub, Prairadda& Leeanansaksiri, Wilairat& Eumkeb, Griangsak. 2018. The Synergy and Mode of Action of Cyperus rotundus L. Extract Plus Ampicillin against Ampicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheypratub, Prairadda…[et al.]. The Synergy and Mode of Action of Cyperus rotundus L. Extract Plus Ampicillin against Ampicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1154853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheypratub, Prairadda& Leeanansaksiri, Wilairat& Eumkeb, Griangsak. The Synergy and Mode of Action of Cyperus rotundus L. Extract Plus Ampicillin against Ampicillin-Resistant Staphylococcus aureus. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1154853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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