Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice

الملخص EN

Background.

Obesity is a main cause of insulin resistance (IR), metabolic syndrome, and fatty liver diseases.

This study evaluated Euphorbia kansui radix (Euphorbia) as a potential treatment option for obesity and obesity-induced IR in obese human and high-fat diet- (HFD-) induced obese mice.

Methods.

In the human study, we analyzed the body weight change of 14 patients who took a single dose of 6 g of Euphorbia powder.

In the animal study, male mice were divided into three groups: normal chow, HFD, and Euphorbia (high-fat diet and 100 mg/Kg Euphorbia once per week).

Body weight, epididymal fat pad weight, fasting blood glucose, fasting insulin, HOMA-IR, and oral glucose tolerance test were measured.

Also, macrophage infiltration and expression of CD68, tumor necrosis factor- (TNF-) α, interferon- (IFN-) γ, and interleukin- (IL-) 6 genes in the liver and adipose tissue were analyzed.

Results.

The human study showed that Euphorbia has a potential effect on body weight loss.

In the in vivo study, body weight, epididymal fat weight, glucose level, IR, expression of CD68, TNF-α, IFN-r, and IL-6 genes, and macrophages in liver and adipose tissue were significantly reduced by Euphorbia.

Conclusions.

These results suggest that Euphorbia attenuates obesity and insulin resistance via anti-inflammatory effects.