Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice
Joint Authors
Lee, Byung-Cheol
Kim, Mia
Na, Hyun-Young
Seol, Mi Hyeon
Lee, Seung-Wook
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Obesity is a main cause of insulin resistance (IR), metabolic syndrome, and fatty liver diseases.
This study evaluated Euphorbia kansui radix (Euphorbia) as a potential treatment option for obesity and obesity-induced IR in obese human and high-fat diet- (HFD-) induced obese mice.
Methods.
In the human study, we analyzed the body weight change of 14 patients who took a single dose of 6 g of Euphorbia powder.
In the animal study, male mice were divided into three groups: normal chow, HFD, and Euphorbia (high-fat diet and 100 mg/Kg Euphorbia once per week).
Body weight, epididymal fat pad weight, fasting blood glucose, fasting insulin, HOMA-IR, and oral glucose tolerance test were measured.
Also, macrophage infiltration and expression of CD68, tumor necrosis factor- (TNF-) α, interferon- (IFN-) γ, and interleukin- (IL-) 6 genes in the liver and adipose tissue were analyzed.
Results.
The human study showed that Euphorbia has a potential effect on body weight loss.
In the in vivo study, body weight, epididymal fat weight, glucose level, IR, expression of CD68, TNF-α, IFN-r, and IL-6 genes, and macrophages in liver and adipose tissue were significantly reduced by Euphorbia.
Conclusions.
These results suggest that Euphorbia attenuates obesity and insulin resistance via anti-inflammatory effects.
American Psychological Association (APA)
Lee, Seung-Wook& Na, Hyun-Young& Seol, Mi Hyeon& Kim, Mia& Lee, Byung-Cheol. 2017. Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154906
Modern Language Association (MLA)
Lee, Seung-Wook…[et al.]. Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1154906
American Medical Association (AMA)
Lee, Seung-Wook& Na, Hyun-Young& Seol, Mi Hyeon& Kim, Mia& Lee, Byung-Cheol. Euphorbia kansui Attenuates Insulin Resistance in Obese Human Subjects and High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1154906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154906