Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Wang, Qiuhong
Zheng, Huijuan
Wei, Junping
Wang, Liansheng
Zhao, Jing
Chen, Shuya
Wei, Fan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Low selenium status is associated with increased risk of Graves’ disease (GD).
While several trials have discussed the efficacy of selenium supplementation for thyroid function, in GD patients, the effectiveness of selenium intake as adjuvant therapy remains unclear.
In this systematic review and meta-analysis, we aimed to determine the efficacy of selenium supplementation on thyroid function in GD patients.
Two reviewers searched PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, and four Chinese databases for studies published up to October 31, 2017.
RCTs comparing the effect of selenium supplementation on thyroid hyperfunction in GD patients on antithyroid medication to placebo were included.
Serum free thyroxine (FT4), free triiodothyronine (FT3), thyrotrophic hormone receptor antibody (TRAb), and thyroid-stimulating hormone (TSH) levels were assessed.
Ten trials involving 796 patients were included.
Random-effects meta-analyses in weighted mean difference (WMD) were performed for 3, 6, and 9 months of supplementation and compared to placebo administration.
Selenium supplementation significantly decreased FT4 (WMD=-0.86 [confidence interval (CI)-1.20 to -0.53]; p=0.756; I2=0.0%) and FT3 (WMD=-0.34 [CI-0.66 to -0.02]; p=0.719; I2=0.0%) levels at 3 months, compared to placebo administration; these findings were consistent at 6 but not 9 months.
TSH levels were more elevated in the group of patients taking selenium than in the control group at 3 and 6, but not 9 months.
TRAb levels decreased at 6 but not 9 months.
At 6 months, patients on selenium supplementation were more likely than controls to show improved thyroid function; however, the effect disappeared at 9 months.
Whether these effects correlate with clinically relevant measures remains to be demonstrated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Huijuan& Wei, Junping& Wang, Liansheng& Wang, Qiuhong& Zhao, Jing& Chen, Shuya…[et al.]. 2018. Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154967
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Huijuan…[et al.]. Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154967
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Huijuan& Wei, Junping& Wang, Liansheng& Wang, Qiuhong& Zhao, Jing& Chen, Shuya…[et al.]. Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154967
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154967
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر