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Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis
Joint Authors
Wang, Qiuhong
Zheng, Huijuan
Wei, Junping
Wang, Liansheng
Zhao, Jing
Chen, Shuya
Wei, Fan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Low selenium status is associated with increased risk of Graves’ disease (GD).
While several trials have discussed the efficacy of selenium supplementation for thyroid function, in GD patients, the effectiveness of selenium intake as adjuvant therapy remains unclear.
In this systematic review and meta-analysis, we aimed to determine the efficacy of selenium supplementation on thyroid function in GD patients.
Two reviewers searched PubMed, Web of Science, the Cochrane Central Register of Controlled Trials, and four Chinese databases for studies published up to October 31, 2017.
RCTs comparing the effect of selenium supplementation on thyroid hyperfunction in GD patients on antithyroid medication to placebo were included.
Serum free thyroxine (FT4), free triiodothyronine (FT3), thyrotrophic hormone receptor antibody (TRAb), and thyroid-stimulating hormone (TSH) levels were assessed.
Ten trials involving 796 patients were included.
Random-effects meta-analyses in weighted mean difference (WMD) were performed for 3, 6, and 9 months of supplementation and compared to placebo administration.
Selenium supplementation significantly decreased FT4 (WMD=-0.86 [confidence interval (CI)-1.20 to -0.53]; p=0.756; I2=0.0%) and FT3 (WMD=-0.34 [CI-0.66 to -0.02]; p=0.719; I2=0.0%) levels at 3 months, compared to placebo administration; these findings were consistent at 6 but not 9 months.
TSH levels were more elevated in the group of patients taking selenium than in the control group at 3 and 6, but not 9 months.
TRAb levels decreased at 6 but not 9 months.
At 6 months, patients on selenium supplementation were more likely than controls to show improved thyroid function; however, the effect disappeared at 9 months.
Whether these effects correlate with clinically relevant measures remains to be demonstrated.
American Psychological Association (APA)
Zheng, Huijuan& Wei, Junping& Wang, Liansheng& Wang, Qiuhong& Zhao, Jing& Chen, Shuya…[et al.]. 2018. Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154967
Modern Language Association (MLA)
Zheng, Huijuan…[et al.]. Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1154967
American Medical Association (AMA)
Zheng, Huijuan& Wei, Junping& Wang, Liansheng& Wang, Qiuhong& Zhao, Jing& Chen, Shuya…[et al.]. Effects of Selenium Supplementation on Graves’ Disease: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1154967
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154967