Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer

المؤلفون المشاركون

Jia, Feng
Ruan, Shu
Li, Jianbo

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-02-08

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Thyroid cancer is one of the most common types of cancer in endocrine system.

In latest studies, harmine has been proved to inhibit the growth of several cancers in vitro and in vivo.

In the current study, we evaluated the in vitro and in vivo anticancer efficiency of harmine against thyroid cancer cell line TPC-1.

The in vitro cytotoxicity of harmine evaluated by XTT assay indicated that harmine suppressed the proliferation of TPC-1 cells in a dose- and time-dependent manner.

Moreover, harmine dose-dependently induced apoptosis of TPC-1 cells through regulating the ratio of Bcl-2/Bax.

The colony forming ability of TPC-1 cells was also time-dependently inhibited by harmine.

The inhibitory effects of harmine on migration and invasion of TPC-1 cells were studied by wound scratching and Transwell assays.

In vivo evaluation showed that harmine effectively inhibited the growth of thyroid cancer in a dose-dependent manner in nude mice.

Therefore, harmine might be a promising herbal medicine in the therapy of thyroid cancer and further efforts are needed to explore this therapeutic strategy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ruan, Shu& Jia, Feng& Li, Jianbo. 2017. Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154981

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ruan, Shu…[et al.]. Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1154981

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ruan, Shu& Jia, Feng& Li, Jianbo. Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154981

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1154981