Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer
Joint Authors
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Thyroid cancer is one of the most common types of cancer in endocrine system.
In latest studies, harmine has been proved to inhibit the growth of several cancers in vitro and in vivo.
In the current study, we evaluated the in vitro and in vivo anticancer efficiency of harmine against thyroid cancer cell line TPC-1.
The in vitro cytotoxicity of harmine evaluated by XTT assay indicated that harmine suppressed the proliferation of TPC-1 cells in a dose- and time-dependent manner.
Moreover, harmine dose-dependently induced apoptosis of TPC-1 cells through regulating the ratio of Bcl-2/Bax.
The colony forming ability of TPC-1 cells was also time-dependently inhibited by harmine.
The inhibitory effects of harmine on migration and invasion of TPC-1 cells were studied by wound scratching and Transwell assays.
In vivo evaluation showed that harmine effectively inhibited the growth of thyroid cancer in a dose-dependent manner in nude mice.
Therefore, harmine might be a promising herbal medicine in the therapy of thyroid cancer and further efforts are needed to explore this therapeutic strategy.
American Psychological Association (APA)
Ruan, Shu& Jia, Feng& Li, Jianbo. 2017. Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154981
Modern Language Association (MLA)
Ruan, Shu…[et al.]. Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1154981
American Medical Association (AMA)
Ruan, Shu& Jia, Feng& Li, Jianbo. Potential Antitumor Effect of Harmine in the Treatment of Thyroid Cancer. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1154981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154981