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Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233
المؤلفون المشاركون
Wanasuntronwong, Aree
Wanakhachornkrai, Oraphan
Phongphanphanee, Penphimon
Isa, Tadashi
Tantisira, Boonyong
Tantisira, Mayuree H.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
GABAergic intercalated neurons of amygdala (ITCs) have recently been shown to be important in the suppression of fear-like behavior.
Effects of ECa233 (a standardized extract of Centella asiatica), previously demonstrated anxiolytic activity, were then investigated on ITCs.
Cluster of GABAergic neurons expressing fluorescence of GFP was identified in GAD67-GFP knock-in mice.
We found that neurons of medial paracapsular ITC were GABAergic neurons exhibiting certain intrinsic electrophysiological properties similar to those demonstrated by ITC neurons at the same location in C57BL/6J mice.
Therefore, we conducted experiments in both C57BL/6J mice and GAD67-GFP knock-in mice.
Excitatory postsynaptic currents (EPSCs) were evoked by stimulation of the external capsule during the whole cell patch-clamp recordings from ITC neurons in brain slices.
ECa233 was found to increase the EPSC peak amplitude in the ITC neurons by about 120%.
The EPSCs in ITC neurons were completely abolished by the application of an AMPA receptor antagonist.
Morphological assessment of the ITC neurons with biocytin demonstrated that most axons of the recorded neurons innervated the central nucleus of the amygdala (CeA).
Therefore, it is highly likely that anxiolytic activity of ECa233 was mediated by increasing activation, via AMPA receptors, of excitatory synaptic input to the GABAergic ITC leading to depression of CeA neurons.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wanasuntronwong, Aree& Wanakhachornkrai, Oraphan& Phongphanphanee, Penphimon& Isa, Tadashi& Tantisira, Boonyong& Tantisira, Mayuree H.. 2018. Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154993
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wanasuntronwong, Aree…[et al.]. Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1154993
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wanasuntronwong, Aree& Wanakhachornkrai, Oraphan& Phongphanphanee, Penphimon& Isa, Tadashi& Tantisira, Boonyong& Tantisira, Mayuree H.. Modulation of Neuronal Activity on Intercalated Neurons of Amygdala Might Underlie Anxiolytic Activity of a Standardized Extract of Centella asiatica ECa233. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1154993
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1154993
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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