Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway

المؤلفون المشاركون

Cui, Yu-Gui
Sun, Dalin
Jin, Baofang
Cai, Bin
Dong, Weihang
Chen, Bing
Deng, Weimin
Jin, Yihan
Liu, Jianguo
Tong, Li
Wu, Ping

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-04-25

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

The testicular microcirculation was an important aspect of testicular physiology and it offered a stable environment for the transport of nutrients and secretary products in the testis.

Yangjing capsule (YC), a traditional Chinese compound herbal prescription, has been proved as an effective drug to ameliorate spermatogenesis, promote testosterone synthesis in vivo, and cure spermatogenesis in clinical practice.

Objective.

This study was aimed at understanding the potential mechanisms of YC exerting angiogenic effects in the mouse spermatogenesis dysfunction model induced by cyclophosphamide (CP) and MLTC-1 cells.

Materials and Methods.

Balb/c mice were randomly divided into five groups: control, CP, CP plus YC (630 mg/kg), CP plus YC (1260 mg/kg), and CP plus YC (2520 mg/kg).

After 30 days, mice were sacrificed and the expressions of endothelial marker CD34+, angiogenic marker VEGFA, VEGFR1, VEGFR2, and eNOS in the testes of the mice were examined; moreover, Leydig cell line MLTC-1 cells were cultured and treated with different concentrations of YC extracts (YCE), and the expressions of VEGFA, VEGFR1, VEGFR2, and eNOS, as well as the secretion of NO, were evaluated.

Results.

We observed that YC significantly increased the expressions of VEGFA, VEGFR1, VEGFR2, and eNOS in testes of CP-treated mice; moreover, YCE has led to increased expressions of VEGFA, VEGFR1, VEGFR2, and eNOS and secretion of NO in MLTC-1 in vitro.

These data suggested that the YC might be an alternative treatment for the dysfunction of testicular microcirculation by promoting the angiogenesis in the testis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Jin, Baofang& Sun, Dalin& Dong, Weihang& Chen, Bing& Deng, Weimin& Cai, Bin…[et al.]. 2020. Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155022

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Jin, Baofang…[et al.]. Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155022

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Jin, Baofang& Sun, Dalin& Dong, Weihang& Chen, Bing& Deng, Weimin& Cai, Bin…[et al.]. Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155022

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1155022