Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway
Joint Authors
Cui, Yu-Gui
Sun, Dalin
Jin, Baofang
Cai, Bin
Dong, Weihang
Chen, Bing
Deng, Weimin
Jin, Yihan
Liu, Jianguo
Tong, Li
Wu, Ping
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The testicular microcirculation was an important aspect of testicular physiology and it offered a stable environment for the transport of nutrients and secretary products in the testis.
Yangjing capsule (YC), a traditional Chinese compound herbal prescription, has been proved as an effective drug to ameliorate spermatogenesis, promote testosterone synthesis in vivo, and cure spermatogenesis in clinical practice.
Objective.
This study was aimed at understanding the potential mechanisms of YC exerting angiogenic effects in the mouse spermatogenesis dysfunction model induced by cyclophosphamide (CP) and MLTC-1 cells.
Materials and Methods.
Balb/c mice were randomly divided into five groups: control, CP, CP plus YC (630 mg/kg), CP plus YC (1260 mg/kg), and CP plus YC (2520 mg/kg).
After 30 days, mice were sacrificed and the expressions of endothelial marker CD34+, angiogenic marker VEGFA, VEGFR1, VEGFR2, and eNOS in the testes of the mice were examined; moreover, Leydig cell line MLTC-1 cells were cultured and treated with different concentrations of YC extracts (YCE), and the expressions of VEGFA, VEGFR1, VEGFR2, and eNOS, as well as the secretion of NO, were evaluated.
Results.
We observed that YC significantly increased the expressions of VEGFA, VEGFR1, VEGFR2, and eNOS in testes of CP-treated mice; moreover, YCE has led to increased expressions of VEGFA, VEGFR1, VEGFR2, and eNOS and secretion of NO in MLTC-1 in vitro.
These data suggested that the YC might be an alternative treatment for the dysfunction of testicular microcirculation by promoting the angiogenesis in the testis.
American Psychological Association (APA)
Jin, Baofang& Sun, Dalin& Dong, Weihang& Chen, Bing& Deng, Weimin& Cai, Bin…[et al.]. 2020. Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155022
Modern Language Association (MLA)
Jin, Baofang…[et al.]. Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1155022
American Medical Association (AMA)
Jin, Baofang& Sun, Dalin& Dong, Weihang& Chen, Bing& Deng, Weimin& Cai, Bin…[et al.]. Yangjing Capsule Can Improve the Function of the Testicular Angiogenesis through Activating VEGFAeNOS Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1155022
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155022