![](/images/graphics-bg.png)
Extraction of Amana edulis Induces Liver Cancer Apoptosis
المؤلفون المشاركون
Feng, Yinglu
Fan, Yueyang
Hou, Xiaowei
Guo, Pengpeng
Lv, Xiuhua
Zhao, Lingling
Wang, Huilan
Zhou, Lu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-07-04
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
HCC is one of the fastest-rising causes of cancer-related death.
Novel therapeutic approaches for treatment are warranted.
The goal of this study is to find effective components from Chinese herbal medicines, which is an important alternative source of anticancer medicine.
To this end, six different herbs were selected from various traditional literatures.
Soxhlet extractor was used to distill the strong polar and weak polar components of each herb.
The inhibitive effect of each component was determined using liver cancer cells BEL7404.
From total of 12 extractions, it was found that the combined crude lysate of Amana edulis from water and ethanol system had the best efficacy.
At the concentration of 0.1 mg/mL, this component has the highest inhibition rate up to 70%.
To investigate the underlying molecular reasons, we observed that the component can significantly induce the liver cancer cells apoptosis and retard the cell reproduction at G2/M stage.
Verification experiments showed that this component also has apparent inhibitive effects on other liver cancer cells, such as HepG2 and Huh7.
On the other hand, it has less effectiveness on another cell line HepaRG, which retains many characteristics of primary human hepatocytes.
The results suggested that there might be highly efficient antihepatoma ingredient in the water and ethanol extraction of Amana edulis.
The pure substances remain to be isolated and further research on their targets is required.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fan, Yueyang& Hou, Xiaowei& Guo, Pengpeng& Lv, Xiuhua& Zhao, Lingling& Wang, Huilan…[et al.]. 2018. Extraction of Amana edulis Induces Liver Cancer Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155031
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fan, Yueyang…[et al.]. Extraction of Amana edulis Induces Liver Cancer Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155031
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fan, Yueyang& Hou, Xiaowei& Guo, Pengpeng& Lv, Xiuhua& Zhao, Lingling& Wang, Huilan…[et al.]. Extraction of Amana edulis Induces Liver Cancer Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155031
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155031
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)