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Extraction of Amana edulis Induces Liver Cancer Apoptosis
Joint Authors
Feng, Yinglu
Fan, Yueyang
Hou, Xiaowei
Guo, Pengpeng
Lv, Xiuhua
Zhao, Lingling
Wang, Huilan
Zhou, Lu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HCC is one of the fastest-rising causes of cancer-related death.
Novel therapeutic approaches for treatment are warranted.
The goal of this study is to find effective components from Chinese herbal medicines, which is an important alternative source of anticancer medicine.
To this end, six different herbs were selected from various traditional literatures.
Soxhlet extractor was used to distill the strong polar and weak polar components of each herb.
The inhibitive effect of each component was determined using liver cancer cells BEL7404.
From total of 12 extractions, it was found that the combined crude lysate of Amana edulis from water and ethanol system had the best efficacy.
At the concentration of 0.1 mg/mL, this component has the highest inhibition rate up to 70%.
To investigate the underlying molecular reasons, we observed that the component can significantly induce the liver cancer cells apoptosis and retard the cell reproduction at G2/M stage.
Verification experiments showed that this component also has apparent inhibitive effects on other liver cancer cells, such as HepG2 and Huh7.
On the other hand, it has less effectiveness on another cell line HepaRG, which retains many characteristics of primary human hepatocytes.
The results suggested that there might be highly efficient antihepatoma ingredient in the water and ethanol extraction of Amana edulis.
The pure substances remain to be isolated and further research on their targets is required.
American Psychological Association (APA)
Fan, Yueyang& Hou, Xiaowei& Guo, Pengpeng& Lv, Xiuhua& Zhao, Lingling& Wang, Huilan…[et al.]. 2018. Extraction of Amana edulis Induces Liver Cancer Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155031
Modern Language Association (MLA)
Fan, Yueyang…[et al.]. Extraction of Amana edulis Induces Liver Cancer Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1155031
American Medical Association (AMA)
Fan, Yueyang& Hou, Xiaowei& Guo, Pengpeng& Lv, Xiuhua& Zhao, Lingling& Wang, Huilan…[et al.]. Extraction of Amana edulis Induces Liver Cancer Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1155031
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155031