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Study on the Mechanism of Sarsasapogenin in Treating Precocious Puberty by Regulating the HPG Axis
المؤلفون المشاركون
Chang, Hong-sheng
Hu, Kaili
Sun, Wenyan
Li, Yu
Zhang, Bo
Zhang, Meng
Guo, Chunyan
Wang, Xiaoling
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The present study aims to investigate the effects and mechanisms of sarsasapogenin resistance to precocious puberty.
Female Sprague Dawley rats were divided into a normal (N) group, model (M) group, leuprolide (L) group, and sarsasapogenin (Sar) group.
Rats at 5 days of age were given a single subcutaneous injection of 300 micrograms of danazol to establish the precocious puberty model.
After 10 days of modeling, drug intervention was started.
The development of the uterus and ovary was observed by hematoxylin and eosin (HE) staining.
The levels of the serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol (E2) were determined by radioimmunoassay.
Also, the expressions of the hypothalamic gonadotropin releasing hormone (GnRH), Kiss-1, G protein-coupled receptor 54 (GPR54), and pituitary gonadotropin releasing hormone receptor (GnRH-R) were detected by RT-PCR.
The results showed that compared with the model group, sarsasapogenin could significantly delay the opening time of vaginal, decreased uterine and ovarian coefficients, and reduced uterine wall thickness.
Moreover, it can significantly downregulate the levels of serum hormones and reduce the expression of GnRH, GnRH-R, and kiss-1.
In summary, our results indicate that sarsasapogenin can regulate the HPG axis through the kiss-1/GPR54 system for therapeutic precocious puberty.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hu, Kaili& Sun, Wenyan& Li, Yu& Zhang, Bo& Zhang, Meng& Guo, Chunyan…[et al.]. 2020. Study on the Mechanism of Sarsasapogenin in Treating Precocious Puberty by Regulating the HPG Axis. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hu, Kaili…[et al.]. Study on the Mechanism of Sarsasapogenin in Treating Precocious Puberty by Regulating the HPG Axis. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hu, Kaili& Sun, Wenyan& Li, Yu& Zhang, Bo& Zhang, Meng& Guo, Chunyan…[et al.]. Study on the Mechanism of Sarsasapogenin in Treating Precocious Puberty by Regulating the HPG Axis. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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