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Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action
المؤلفون المشاركون
Arachchige, Sirimal Premakumara Galbada
Handunnetti, Shiroma
Chandrakanthan, Madhuvanthi
Kathirgamanathar, Selvaluxmy
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-28
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
This study aimed at investigating the anti-inflammatory potential of essential oil from rhizome and leaf of Alpinia calcarata Rosc.
(ACEO) with the focus of its topical anti-inflammatory activity along with its dominant compounds 1,8-cineole and α-terpineol using mouse ear edema model.
ACEOs were analyzed by GC-MS.
The anti-inflammatory activity was determined by studying the inhibition of overproduction of proinflammatory mediators—nitric oxide, reactive oxygen species, prostaglandins, cyclooxygenases, and cytokines induced by lipopolysaccharides in murine macrophages.
Topical anti-inflammatory and antinociceptive activity was studied by 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin inflammation and formalin-induced pain model in mice, respectively.
Rhizome oil has 1,8-cineole (31.08%), α-terpineol (10.31%), and fenchyl acetate (10.73%) as major compounds whereas the ACEO from leaves has 1,8-cineole (38.45%), a-terpineol (11.62%), and camphor (10%).
ACEOs reduced the production of inflammatory mediators in vitro in a concentration-dependent manner.
Further, ACEO and its major compounds reduced ear thickness, weight, myeloperoxidase, and cytokines significantly (p<0.01) in mouse ear.
Dose-dependent reduction in flinching and licking in both the phases of pain sensation concludes the topical analgesic effect.
Our findings suggest the potency of topical use of ACEOs for inflammatory disease conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chandrakanthan, Madhuvanthi& Handunnetti, Shiroma& Arachchige, Sirimal Premakumara Galbada& Kathirgamanathar, Selvaluxmy. 2020. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1155056
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chandrakanthan, Madhuvanthi…[et al.]. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1155056
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chandrakanthan, Madhuvanthi& Handunnetti, Shiroma& Arachchige, Sirimal Premakumara Galbada& Kathirgamanathar, Selvaluxmy. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1155056
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155056
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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