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Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action
Joint Authors
Arachchige, Sirimal Premakumara Galbada
Handunnetti, Shiroma
Chandrakanthan, Madhuvanthi
Kathirgamanathar, Selvaluxmy
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-28
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
This study aimed at investigating the anti-inflammatory potential of essential oil from rhizome and leaf of Alpinia calcarata Rosc.
(ACEO) with the focus of its topical anti-inflammatory activity along with its dominant compounds 1,8-cineole and α-terpineol using mouse ear edema model.
ACEOs were analyzed by GC-MS.
The anti-inflammatory activity was determined by studying the inhibition of overproduction of proinflammatory mediators—nitric oxide, reactive oxygen species, prostaglandins, cyclooxygenases, and cytokines induced by lipopolysaccharides in murine macrophages.
Topical anti-inflammatory and antinociceptive activity was studied by 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin inflammation and formalin-induced pain model in mice, respectively.
Rhizome oil has 1,8-cineole (31.08%), α-terpineol (10.31%), and fenchyl acetate (10.73%) as major compounds whereas the ACEO from leaves has 1,8-cineole (38.45%), a-terpineol (11.62%), and camphor (10%).
ACEOs reduced the production of inflammatory mediators in vitro in a concentration-dependent manner.
Further, ACEO and its major compounds reduced ear thickness, weight, myeloperoxidase, and cytokines significantly (p<0.01) in mouse ear.
Dose-dependent reduction in flinching and licking in both the phases of pain sensation concludes the topical analgesic effect.
Our findings suggest the potency of topical use of ACEOs for inflammatory disease conditions.
American Psychological Association (APA)
Chandrakanthan, Madhuvanthi& Handunnetti, Shiroma& Arachchige, Sirimal Premakumara Galbada& Kathirgamanathar, Selvaluxmy. 2020. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1155056
Modern Language Association (MLA)
Chandrakanthan, Madhuvanthi…[et al.]. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-19.
https://search.emarefa.net/detail/BIM-1155056
American Medical Association (AMA)
Chandrakanthan, Madhuvanthi& Handunnetti, Shiroma& Arachchige, Sirimal Premakumara Galbada& Kathirgamanathar, Selvaluxmy. Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-19.
https://search.emarefa.net/detail/BIM-1155056
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155056