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Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
المؤلفون المشاركون
Lin, Yi-Wen
Ho, Tin-Yun
Cheng, Chin-Yi
Chen, Chao-Hsiang
Tang, Nou-Ying
Hsieh, Ching-Liang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-23
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain.
An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss.
Herbal medicines offer alternative treatment options for epilepsy because of their low cost and few side effects.
We established a rat epilepsy model by injecting kainic acid (KA, 12 mg/kg, i.p.) and subsequently investigated the effect of Uncaria rhynchophylla (UR) and its underlying mechanisms.
Electroencephalogram and epileptic behaviors revealed that the KA injection induced epileptic seizures.
Following KA injection, S100B levels increased in the hippocampus.
This phenomenon was attenuated by the oral administration of UR and valproic acid (VA, 250 mg/kg).
Both drugs significantly reversed receptor potentiation for advanced glycation end product proteins.
Rats with KA-induced epilepsy exhibited no increase in the expression of metabotropic glutamate receptor 3, monocyte chemoattractant protein 1, and chemokine receptor type 2, which play a role in inflammation.
Our results provide novel and detailed mechanisms, explaining the role of UR in KA-induced epileptic seizures in hippocampal CA1 neurons.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Nou-Ying& Lin, Yi-Wen& Ho, Tin-Yun& Cheng, Chin-Yi& Chen, Chao-Hsiang& Hsieh, Ching-Liang. 2017. Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1155061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Nou-Ying…[et al.]. Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1155061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Nou-Ying& Lin, Yi-Wen& Ho, Tin-Yun& Cheng, Chin-Yi& Chen, Chao-Hsiang& Hsieh, Ching-Liang. Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1155061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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