Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats
Joint Authors
Lin, Yi-Wen
Ho, Tin-Yun
Cheng, Chin-Yi
Chen, Chao-Hsiang
Tang, Nou-Ying
Hsieh, Ching-Liang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Epileptic seizures are crucial clinical manifestations of recurrent neuronal discharges in the brain.
An imbalance between the excitatory and inhibitory neuronal discharges causes brain damage and cell loss.
Herbal medicines offer alternative treatment options for epilepsy because of their low cost and few side effects.
We established a rat epilepsy model by injecting kainic acid (KA, 12 mg/kg, i.p.) and subsequently investigated the effect of Uncaria rhynchophylla (UR) and its underlying mechanisms.
Electroencephalogram and epileptic behaviors revealed that the KA injection induced epileptic seizures.
Following KA injection, S100B levels increased in the hippocampus.
This phenomenon was attenuated by the oral administration of UR and valproic acid (VA, 250 mg/kg).
Both drugs significantly reversed receptor potentiation for advanced glycation end product proteins.
Rats with KA-induced epilepsy exhibited no increase in the expression of metabotropic glutamate receptor 3, monocyte chemoattractant protein 1, and chemokine receptor type 2, which play a role in inflammation.
Our results provide novel and detailed mechanisms, explaining the role of UR in KA-induced epileptic seizures in hippocampal CA1 neurons.
American Psychological Association (APA)
Tang, Nou-Ying& Lin, Yi-Wen& Ho, Tin-Yun& Cheng, Chin-Yi& Chen, Chao-Hsiang& Hsieh, Ching-Liang. 2017. Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1155061
Modern Language Association (MLA)
Tang, Nou-Ying…[et al.]. Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1155061
American Medical Association (AMA)
Tang, Nou-Ying& Lin, Yi-Wen& Ho, Tin-Yun& Cheng, Chin-Yi& Chen, Chao-Hsiang& Hsieh, Ching-Liang. Long-Term Intake of Uncaria rhynchophylla Reduces S100B and RAGE Protein Levels in Kainic Acid-Induced Epileptic Seizures Rats. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1155061
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155061