Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle
المؤلفون المشاركون
Liu, Qing-Hua
Ma, Liqun
Huang, Jun
Yang, Yongle
Wen, Nana
Zhou, Wan
Cai, Congli
Shen, Jinhua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Artemisia annua L.
belongs to the Asteraceae family, which is indigenous to China.
It has valuable pharmacological properties, such as antimalarial, anti-inflammatory, and anticancer properties.
However, whether it possesses antiasthma properties is unknown.
In the current study, chloroform extract of Artemisia annua L.
(CEAA) was prepared, and we found that CEAA completely eliminated acetylcholine (ACh) or high K+-elicited (80 mM) contractions of mouse tracheal rings (TRs).
Patch-clamp technique and ion channel blockers were employed to explore the underlying mechanisms of the relaxant effect of CEAA.
In whole-cell current recording, CEAA almost fully abolished voltage-dependent Ca2+ channel (VDCC) currents and markedly enhanced large conductance Ca2+-activated K+ (BK) channel currents on airway smooth muscle cells (ASMCs).
In single channel current recording, CEAA increased the opening probability but had no effect on the single channel conductance of BK channels.
However, under paxilline-preincubated (a selective BK channel blocker) conditions, CEAA only slightly increased BK channel currents.
These results indicate that CEAA may contain active components with potent antiasthma activity.
The abolished VDCCs by CEAA may mainly contribute to the underlying mechanism through which it acts as an effective antiasthmatic compound, but the enhanced BK currents might play a less important role in the antiasthmatic effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Jun& Ma, Liqun& Yang, Yongle& Wen, Nana& Zhou, Wan& Cai, Congli…[et al.]. 2017. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1155100
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Jun…[et al.]. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1155100
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Jun& Ma, Liqun& Yang, Yongle& Wen, Nana& Zhou, Wan& Cai, Congli…[et al.]. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1155100
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155100
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر