Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle
Joint Authors
Liu, Qing-Hua
Ma, Liqun
Huang, Jun
Yang, Yongle
Wen, Nana
Zhou, Wan
Cai, Congli
Shen, Jinhua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Artemisia annua L.
belongs to the Asteraceae family, which is indigenous to China.
It has valuable pharmacological properties, such as antimalarial, anti-inflammatory, and anticancer properties.
However, whether it possesses antiasthma properties is unknown.
In the current study, chloroform extract of Artemisia annua L.
(CEAA) was prepared, and we found that CEAA completely eliminated acetylcholine (ACh) or high K+-elicited (80 mM) contractions of mouse tracheal rings (TRs).
Patch-clamp technique and ion channel blockers were employed to explore the underlying mechanisms of the relaxant effect of CEAA.
In whole-cell current recording, CEAA almost fully abolished voltage-dependent Ca2+ channel (VDCC) currents and markedly enhanced large conductance Ca2+-activated K+ (BK) channel currents on airway smooth muscle cells (ASMCs).
In single channel current recording, CEAA increased the opening probability but had no effect on the single channel conductance of BK channels.
However, under paxilline-preincubated (a selective BK channel blocker) conditions, CEAA only slightly increased BK channel currents.
These results indicate that CEAA may contain active components with potent antiasthma activity.
The abolished VDCCs by CEAA may mainly contribute to the underlying mechanism through which it acts as an effective antiasthmatic compound, but the enhanced BK currents might play a less important role in the antiasthmatic effects.
American Psychological Association (APA)
Huang, Jun& Ma, Liqun& Yang, Yongle& Wen, Nana& Zhou, Wan& Cai, Congli…[et al.]. 2017. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1155100
Modern Language Association (MLA)
Huang, Jun…[et al.]. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1155100
American Medical Association (AMA)
Huang, Jun& Ma, Liqun& Yang, Yongle& Wen, Nana& Zhou, Wan& Cai, Congli…[et al.]. Chloroform Extract of Artemisia annua L. Relaxes Mouse Airway Smooth Muscle. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1155100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155100