Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop
المؤلفون المشاركون
Chen, Cheng
You, Fei
Wu, FengHua
Luo, YuShen
zheng, GuoHua
Xu, HanLin
Liu, Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Natural plants are considered as a huge treasure for anticancer.
Amomum tsaoko, a plant of Zingiberaceae, is used widely as a food and traditional medicine in East Asia.
In previous studies, Amomum tsaoko has antitumor effect on liver cancer cells, but the mechanism is not clear.
Here, we demonstrated that ethanol extract from Amomum tsaoko (At-EE) could inhibit ovarian cancer and decrease angiogenesis in vivo.
At-EE did not influence vascular endothelial cells directly, but decreased IL-6 and VEGF secreted by ovarian cancer cells to inhibit angiogenesis through inhibition of p-STAT3 and NF-kB activation.
In addition, we demonstrated that p-STAT3 and NF-kB could adjust each other and IL-6 and VEGF also mediate p-STAT3 and NF-kB too, which created a loop.
In addition, At-EE interrupted p-STAT3/NF-kB/IL-6 and VEGF loop through induced ER stress.
These results reveal that p-STAT3/NF-kB/IL-6 and VEGF is a cascade amplification loop in ovarian cancer for angiogenesis, and induced ER stress can interrupt it.
Taken together, this work explored the anticancer activities of Amomum tsaoko, which could be a potential therapeutic candidate in the treatment of ovarian cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Cheng& You, Fei& Wu, FengHua& Luo, YuShen& zheng, GuoHua& Xu, HanLin…[et al.]. 2020. Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155179
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Cheng…[et al.]. Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155179
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Cheng& You, Fei& Wu, FengHua& Luo, YuShen& zheng, GuoHua& Xu, HanLin…[et al.]. Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155179
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155179
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر