Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop
Joint Authors
Chen, Cheng
You, Fei
Wu, FengHua
Luo, YuShen
zheng, GuoHua
Xu, HanLin
Liu, Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Natural plants are considered as a huge treasure for anticancer.
Amomum tsaoko, a plant of Zingiberaceae, is used widely as a food and traditional medicine in East Asia.
In previous studies, Amomum tsaoko has antitumor effect on liver cancer cells, but the mechanism is not clear.
Here, we demonstrated that ethanol extract from Amomum tsaoko (At-EE) could inhibit ovarian cancer and decrease angiogenesis in vivo.
At-EE did not influence vascular endothelial cells directly, but decreased IL-6 and VEGF secreted by ovarian cancer cells to inhibit angiogenesis through inhibition of p-STAT3 and NF-kB activation.
In addition, we demonstrated that p-STAT3 and NF-kB could adjust each other and IL-6 and VEGF also mediate p-STAT3 and NF-kB too, which created a loop.
In addition, At-EE interrupted p-STAT3/NF-kB/IL-6 and VEGF loop through induced ER stress.
These results reveal that p-STAT3/NF-kB/IL-6 and VEGF is a cascade amplification loop in ovarian cancer for angiogenesis, and induced ER stress can interrupt it.
Taken together, this work explored the anticancer activities of Amomum tsaoko, which could be a potential therapeutic candidate in the treatment of ovarian cancer.
American Psychological Association (APA)
Chen, Cheng& You, Fei& Wu, FengHua& Luo, YuShen& zheng, GuoHua& Xu, HanLin…[et al.]. 2020. Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155179
Modern Language Association (MLA)
Chen, Cheng…[et al.]. Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1155179
American Medical Association (AMA)
Chen, Cheng& You, Fei& Wu, FengHua& Luo, YuShen& zheng, GuoHua& Xu, HanLin…[et al.]. Antiangiogenesis Efficacy of Ethanol Extract from Amomum tsaoko in Ovarian Cancer through Inducing ER Stress to Suppress p-STAT3NF-kBIL-6 and VEGF Loop. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1155179
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155179