Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia
المؤلفون المشاركون
Chen, Gong
Zheng, Shan
Zhuang, Peijun
Sun, Song
Huang, Yanlei
Dong, Rui
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-11-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
To detail the effects of vitamin D (VD) deficiency and assess the relationships between VD deficiency and liver function and liver fibrosis in patients with biliary atresia (BA).
Methods.
In this study, BA patients confirmed by intraoperative cholangiography were enrolled between January 2017 and February 2019.
Preoperative serum 25-(OH)D level, liver function, serum biomarker levels of liver fibrosis, and histopathologic features were recorded.
Deficiency, insufficiency, and sufficiency of VD were defined as serum 25-(OH)D concentrations of <10, 10-20, and >20 ng/ml, respectively.
Associations between serum 25-(OH)D level and liver function and liver fibrosis were analyzed.
Results.
A total of 161 BA infants were included.
The median (interquartile range (IQR)) serum 25-(OH)D level in all patients was 7.56 (IQR: 4.48–11.40) ng/ml.
The rates of 25-(OH)D deficiency, insufficiency, and sufficiency were 67.1% (108/161), 29.2% (47/161), and 3.7% (6/161), respectively.
Serum 25-(OH)D level was negatively correlated with alkaline phosphatase (r=‐0.232, P=0.003).
After adjusting for age, a decrease in serum 25-(OH)D level was correlated with the increase of the Batts-Ludwig stage score (odds ratio (OR): 0.94, 95% confidence interval (CI): 0.88–0.99; P=0.028).
Serum 25-(OH)D level was also correlated with the N-terminal propeptide of type III procollagen (PIIINP) (r=‐0.246, P=0.002).
Additionally, PIIINP (P=0.038) and ALP (P=0.031) were independently associated with serum 25-(OH)D level.
Conclusions.
VD deficiency was common and inversely correlated with liver fibrosis in BA patients.
Furthermore, VD was not correlated with liver function except alkaline phosphatase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhuang, Peijun& Sun, Song& Dong, Rui& Chen, Gong& Huang, Yanlei& Zheng, Shan. 2019. Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155209
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhuang, Peijun…[et al.]. Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155209
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhuang, Peijun& Sun, Song& Dong, Rui& Chen, Gong& Huang, Yanlei& Zheng, Shan. Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155209
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155209
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر