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Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia
Joint Authors
Chen, Gong
Zheng, Shan
Zhuang, Peijun
Sun, Song
Huang, Yanlei
Dong, Rui
Source
Gastroenterology Research and Practice
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-11-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objectives.
To detail the effects of vitamin D (VD) deficiency and assess the relationships between VD deficiency and liver function and liver fibrosis in patients with biliary atresia (BA).
Methods.
In this study, BA patients confirmed by intraoperative cholangiography were enrolled between January 2017 and February 2019.
Preoperative serum 25-(OH)D level, liver function, serum biomarker levels of liver fibrosis, and histopathologic features were recorded.
Deficiency, insufficiency, and sufficiency of VD were defined as serum 25-(OH)D concentrations of <10, 10-20, and >20 ng/ml, respectively.
Associations between serum 25-(OH)D level and liver function and liver fibrosis were analyzed.
Results.
A total of 161 BA infants were included.
The median (interquartile range (IQR)) serum 25-(OH)D level in all patients was 7.56 (IQR: 4.48–11.40) ng/ml.
The rates of 25-(OH)D deficiency, insufficiency, and sufficiency were 67.1% (108/161), 29.2% (47/161), and 3.7% (6/161), respectively.
Serum 25-(OH)D level was negatively correlated with alkaline phosphatase (r=‐0.232, P=0.003).
After adjusting for age, a decrease in serum 25-(OH)D level was correlated with the increase of the Batts-Ludwig stage score (odds ratio (OR): 0.94, 95% confidence interval (CI): 0.88–0.99; P=0.028).
Serum 25-(OH)D level was also correlated with the N-terminal propeptide of type III procollagen (PIIINP) (r=‐0.246, P=0.002).
Additionally, PIIINP (P=0.038) and ALP (P=0.031) were independently associated with serum 25-(OH)D level.
Conclusions.
VD deficiency was common and inversely correlated with liver fibrosis in BA patients.
Furthermore, VD was not correlated with liver function except alkaline phosphatase.
American Psychological Association (APA)
Zhuang, Peijun& Sun, Song& Dong, Rui& Chen, Gong& Huang, Yanlei& Zheng, Shan. 2019. Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155209
Modern Language Association (MLA)
Zhuang, Peijun…[et al.]. Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia. Gastroenterology Research and Practice No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1155209
American Medical Association (AMA)
Zhuang, Peijun& Sun, Song& Dong, Rui& Chen, Gong& Huang, Yanlei& Zheng, Shan. Associations between Vitamin D and Liver Function and Liver Fibrosis in Patients with Biliary Atresia. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1155209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155209