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Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats
المؤلفون المشاركون
Aili, Maimaiti
Huo, Shixia
Han, Meng-ting
Aibai, Silafu
Li, Zhi-Jian
Wang, Bin
Wang, Chun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-17
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Artemisia rupestris L.
is the perennial herb of rupestris belonging to Artemisia (Compositae), which is wildly distributed in Xinjiang (China), middle Asia, and Europe.
It is known to have anti-inflammatory, hepatoprotective, immune function regulation, and gastrointestinal function regulation effects.
AR is used to treat digestive diseases, but the effects of AR on antifunctional dyspepsia (FD) activity have not yet been reported.
In this study, we aimed to investigate the therapeutic effects of Artemisia rupestris L.
extract (ARE) on gastrointestinal hormones and brain-gut peptide in functional dyspepsia (FD) rats.
Sixty Sprague-Dawley rats were randomly divided into 6 groups.
An FD rat model was established by irregular tail clamp stimulation for 14 days except the blank group.
After FD rat models, the blank group and model group were given menstruum, and the medicated rats were given corresponding medicine for 14 days.
The general observations, bodyweight, and food intake were observed, and the content of serum gastrin (GAS), plasma motilin (MTL), plasma vasoactive intestinal peptide (VIP), and plasma somatostatin (SS) by the enzyme-linked immunosorbent assay was observed.
The content of plasma VIP and plasma SS in the ARE group was significantly lower than in the model group, and the content of serum GAS and plasma MTL was increased in the ARE group; the GAS expression of antrum and hypothalamus was increased in the ARE group, and SS expression of antrum and hypothalamus was decreased in the ARE group by immunohistochemical detection; the results of semiquantitative reverse transcription polymerase chain reaction (RT-PCR) indicate that ARE inhibits the mRNA expression of VIP.
Our results suggest that ARE can recover gastrointestinal hormone levels and regulation of the peripheral and central nervous system and alter gut peptide levels, which confirm the therapeutic effect of ARE on functional dyspepsia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Chun& Wang, Bin& Aili, Maimaiti& Huo, Shixia& Han, Meng-ting& Aibai, Silafu…[et al.]. 2020. Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155245
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Chun…[et al.]. Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1155245
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Chun& Wang, Bin& Aili, Maimaiti& Huo, Shixia& Han, Meng-ting& Aibai, Silafu…[et al.]. Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155245
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155245
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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