Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats
Joint Authors
Aili, Maimaiti
Huo, Shixia
Han, Meng-ting
Aibai, Silafu
Li, Zhi-Jian
Wang, Bin
Wang, Chun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Artemisia rupestris L.
is the perennial herb of rupestris belonging to Artemisia (Compositae), which is wildly distributed in Xinjiang (China), middle Asia, and Europe.
It is known to have anti-inflammatory, hepatoprotective, immune function regulation, and gastrointestinal function regulation effects.
AR is used to treat digestive diseases, but the effects of AR on antifunctional dyspepsia (FD) activity have not yet been reported.
In this study, we aimed to investigate the therapeutic effects of Artemisia rupestris L.
extract (ARE) on gastrointestinal hormones and brain-gut peptide in functional dyspepsia (FD) rats.
Sixty Sprague-Dawley rats were randomly divided into 6 groups.
An FD rat model was established by irregular tail clamp stimulation for 14 days except the blank group.
After FD rat models, the blank group and model group were given menstruum, and the medicated rats were given corresponding medicine for 14 days.
The general observations, bodyweight, and food intake were observed, and the content of serum gastrin (GAS), plasma motilin (MTL), plasma vasoactive intestinal peptide (VIP), and plasma somatostatin (SS) by the enzyme-linked immunosorbent assay was observed.
The content of plasma VIP and plasma SS in the ARE group was significantly lower than in the model group, and the content of serum GAS and plasma MTL was increased in the ARE group; the GAS expression of antrum and hypothalamus was increased in the ARE group, and SS expression of antrum and hypothalamus was decreased in the ARE group by immunohistochemical detection; the results of semiquantitative reverse transcription polymerase chain reaction (RT-PCR) indicate that ARE inhibits the mRNA expression of VIP.
Our results suggest that ARE can recover gastrointestinal hormone levels and regulation of the peripheral and central nervous system and alter gut peptide levels, which confirm the therapeutic effect of ARE on functional dyspepsia.
American Psychological Association (APA)
Wang, Chun& Wang, Bin& Aili, Maimaiti& Huo, Shixia& Han, Meng-ting& Aibai, Silafu…[et al.]. 2020. Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155245
Modern Language Association (MLA)
Wang, Chun…[et al.]. Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-12.
https://search.emarefa.net/detail/BIM-1155245
American Medical Association (AMA)
Wang, Chun& Wang, Bin& Aili, Maimaiti& Huo, Shixia& Han, Meng-ting& Aibai, Silafu…[et al.]. Effect of Artemisia rupestris L. Extract on Gastrointestinal Hormones and Brain-Gut Peptides in Functional Dyspepsia Rats. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-12.
https://search.emarefa.net/detail/BIM-1155245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155245