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Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro
المؤلفون المشاركون
Frajese, Giovanni Vanni
Benvenuto, Monica
Mattera, Rosanna
Giampaoli, Saverio
Ambrosin, Elena
Bernardini, Roberta
Giganti, Maria Gabriella
Albonici, Loredana
Dus, Ivan
Manzari, Vittorio
Modesti, Andrea
Mattei, Maurizio
Bei, Roberto
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Electrochemical reduced water (ERW) has been proposed to have beneficial effects on human health due to its rich content of H2 and the presence of platinum nanoparticles with antioxidant effects.
Many studies have demonstrated that ERW scavenging properties are able to reduce the damage caused by oxidative stress in different experimental models.
Although few in vivo studies have been reported, it has been demonstrated that ERW may display anticancer effects by induction of tumor cells apoptosis and reduction of both angiogenesis and inflammation.
In this study, we show that ERW treatment of MCF-7, MDA-MB-453, and mouse (TUBO) breast cancer cells inhibited cell survival in a time-dependent fashion.
ERW decreased ErbB2/neu expression and impaired pERK1/ERK2 and AKT phosphorylation in breast cancer cells.
In addition, ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors.
Our in vivo results showed that ERW treatment of transgenic BALB-neuT mice delayed the development of mammary tumors compared to the control.
In addition, ERW induced a significant prolongation of tumor-free survival and a reduction in tumor multiplicity.
Overall, these results suggest a potential beneficial role of ERW in inhibiting cancer cells growth.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Frajese, Giovanni Vanni& Benvenuto, Monica& Mattera, Rosanna& Giampaoli, Saverio& Ambrosin, Elena& Bernardini, Roberta…[et al.]. 2018. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Frajese, Giovanni Vanni…[et al.]. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1155277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Frajese, Giovanni Vanni& Benvenuto, Monica& Mattera, Rosanna& Giampaoli, Saverio& Ambrosin, Elena& Bernardini, Roberta…[et al.]. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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