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Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro
Joint Authors
Frajese, Giovanni Vanni
Benvenuto, Monica
Mattera, Rosanna
Giampaoli, Saverio
Ambrosin, Elena
Bernardini, Roberta
Giganti, Maria Gabriella
Albonici, Loredana
Dus, Ivan
Manzari, Vittorio
Modesti, Andrea
Mattei, Maurizio
Bei, Roberto
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Electrochemical reduced water (ERW) has been proposed to have beneficial effects on human health due to its rich content of H2 and the presence of platinum nanoparticles with antioxidant effects.
Many studies have demonstrated that ERW scavenging properties are able to reduce the damage caused by oxidative stress in different experimental models.
Although few in vivo studies have been reported, it has been demonstrated that ERW may display anticancer effects by induction of tumor cells apoptosis and reduction of both angiogenesis and inflammation.
In this study, we show that ERW treatment of MCF-7, MDA-MB-453, and mouse (TUBO) breast cancer cells inhibited cell survival in a time-dependent fashion.
ERW decreased ErbB2/neu expression and impaired pERK1/ERK2 and AKT phosphorylation in breast cancer cells.
In addition, ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors.
Our in vivo results showed that ERW treatment of transgenic BALB-neuT mice delayed the development of mammary tumors compared to the control.
In addition, ERW induced a significant prolongation of tumor-free survival and a reduction in tumor multiplicity.
Overall, these results suggest a potential beneficial role of ERW in inhibiting cancer cells growth.
American Psychological Association (APA)
Frajese, Giovanni Vanni& Benvenuto, Monica& Mattera, Rosanna& Giampaoli, Saverio& Ambrosin, Elena& Bernardini, Roberta…[et al.]. 2018. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155277
Modern Language Association (MLA)
Frajese, Giovanni Vanni…[et al.]. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1155277
American Medical Association (AMA)
Frajese, Giovanni Vanni& Benvenuto, Monica& Mattera, Rosanna& Giampaoli, Saverio& Ambrosin, Elena& Bernardini, Roberta…[et al.]. Electrochemically Reduced Water Delays Mammary Tumors Growth in Mice and Inhibits Breast Cancer Cells Survival In Vitro. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1155277
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155277