Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex

المؤلفون المشاركون

Wu, Huangan
Liu, Huirong
Zhao, Jimeng
Weng, Zhijun
Ma, Zhe
Zhao, Min
Wang, Zhaoqin
Zhang, Fang
Li, Guona
Xin, Yuhu

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-06-12

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Objective.

To explore whether the effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in rats with irritable bowel syndrome (IBS) is related to the changes of astrocyte activation in the medial thalamus (MT) and anterior cingulate cortex (ACC).

Method.

Male Sprague-Dawley rats were randomly divided into the normal control (NC) group, model control (MC) group, electroacupuncture (EA) group, and fluorocitrate (FCA) group.

A model of visceral hypersensitivity was established by neonatal colorectal irritation.

In the EA group, needles were inserted into the skin at the Tianshu (ST25) and Shangjuxu (ST37) acupoints, once a day for 7 days.

The FCA group received intrathecal injection of FCA on the 1st, 4th, and 7th days.

Visceral hypersensitivity was evaluated by the abdominal withdrawal reflex (AWR), and glial fibrillary acidic protein (GFAP) mRNA and protein levels in the MT and ACC were detected by real-time PCR, immunohistochemistry, and western blots.

Results.

The AWR score in the MC group was significantly higher than in the NC group, and EA and FCA reduced the AWR score of VH rats.

GFAP mRNA and protein levels in the MT and ACC of rats in the MC group were significantly increased compared with the NC group.

After either electroacupuncture or fluorocitrate, GFAP mRNA and protein levels in the MT and ACC were both clearly reduced.

Conclusion.

Electroacupuncture alleviates IBS visceral hypersensitivity by inhibiting the activation of astrocytes in the MT and ACC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhao, Min& Wang, Zhaoqin& Weng, Zhijun& Zhang, Fang& Li, Guona& Ma, Zhe…[et al.]. 2020. Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155286

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhao, Min…[et al.]. Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155286

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhao, Min& Wang, Zhaoqin& Weng, Zhijun& Zhang, Fang& Li, Guona& Ma, Zhe…[et al.]. Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155286

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1155286