Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex
Joint Authors
Wu, Huangan
Liu, Huirong
Zhao, Jimeng
Weng, Zhijun
Ma, Zhe
Zhao, Min
Wang, Zhaoqin
Zhang, Fang
Li, Guona
Xin, Yuhu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-06-12
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To explore whether the effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in rats with irritable bowel syndrome (IBS) is related to the changes of astrocyte activation in the medial thalamus (MT) and anterior cingulate cortex (ACC).
Method.
Male Sprague-Dawley rats were randomly divided into the normal control (NC) group, model control (MC) group, electroacupuncture (EA) group, and fluorocitrate (FCA) group.
A model of visceral hypersensitivity was established by neonatal colorectal irritation.
In the EA group, needles were inserted into the skin at the Tianshu (ST25) and Shangjuxu (ST37) acupoints, once a day for 7 days.
The FCA group received intrathecal injection of FCA on the 1st, 4th, and 7th days.
Visceral hypersensitivity was evaluated by the abdominal withdrawal reflex (AWR), and glial fibrillary acidic protein (GFAP) mRNA and protein levels in the MT and ACC were detected by real-time PCR, immunohistochemistry, and western blots.
Results.
The AWR score in the MC group was significantly higher than in the NC group, and EA and FCA reduced the AWR score of VH rats.
GFAP mRNA and protein levels in the MT and ACC of rats in the MC group were significantly increased compared with the NC group.
After either electroacupuncture or fluorocitrate, GFAP mRNA and protein levels in the MT and ACC were both clearly reduced.
Conclusion.
Electroacupuncture alleviates IBS visceral hypersensitivity by inhibiting the activation of astrocytes in the MT and ACC.
American Psychological Association (APA)
Zhao, Min& Wang, Zhaoqin& Weng, Zhijun& Zhang, Fang& Li, Guona& Ma, Zhe…[et al.]. 2020. Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155286
Modern Language Association (MLA)
Zhao, Min…[et al.]. Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155286
American Medical Association (AMA)
Zhao, Min& Wang, Zhaoqin& Weng, Zhijun& Zhang, Fang& Li, Guona& Ma, Zhe…[et al.]. Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155286