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(+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer
المؤلفون المشاركون
Wu, Wei
Hou, Bing
Tang, Changli
Liu, Fucheng
Yang, Jie
Pan, Tao
Si, Ke
Lu, Deyun
Wang, Xiaoxiang
Wang, Jing
Xiong, Xing
Liu, Ji
Xie, Chunguang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-12
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Inhibition of tumor cell migration is a treatment strategy for patients with colorectal cancer (CRC).
SCF-dependent activation of c-KIT is responsible for migration of c-KIT positive [c-KIT(+)] cells of CRC.
Drug resistance to Imatinib Mesylate (c-KIT inhibitor) has emerged.
Inhibition of mTOR can induce autophagic degradation of c-KIT.
(+)-usnic acid [(+)-UA], isolated from lichens, has two major functions including induction of proton shuttle and targeting inhibition of mTOR.
To reduce hepatotoxicity, the treatment concentration of (+)-UA should be lower than 10 μM.
HCT116 cells and LS174 cells were employed to investigate the inhibiting effect of (+)-UA (<10 μM) on SCF-mediated migration of c-KIT(+) CRC cells.
HCT116 cells were employed to investigate the molecular mechanisms.
The results indicated that firstly, 8 μM (+)-UA decreased ATP content via uncoupling; secondly, 8 μM (+)-UA induced mTOR inhibition, thereby mediated activation suppression of PKC-A, and induced the autophagy of the completed autophagic flux that resulted in the autophagic degradation and transcriptional inhibition of c-KIT and the increase in LDH release; ultimately, 8 μM (+)-UA inhibited SCF-mediated migration of CRC c-KIT(+) cells.
Taken together, 8 μM could be determined as the effective concentration for (+)-UA to inhibit SCF-mediated migration of CRC c-KIT(+) cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Wei& Hou, Bing& Tang, Changli& Liu, Fucheng& Yang, Jie& Pan, Tao…[et al.]. 2018. (+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Wei…[et al.]. (+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1155421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Wei& Hou, Bing& Tang, Changli& Liu, Fucheng& Yang, Jie& Pan, Tao…[et al.]. (+)-Usnic Acid Inhibits Migration of c-KIT Positive Cells in Human Colorectal Cancer. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1155421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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