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Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease
المؤلفون المشاركون
Song, Zhenyan
Yin, Fang
Xiang, Biao
Lan, Bin
Cheng, Shaowu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-06-27
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
In traditional Chinese medicine (TCM), Acori Tatarinowii Rhizoma (ATR) is widely used to treat memory and cognition dysfunction.
This study aimed to confirm evidence regarding the potential therapeutic effect of ATR on Alzheimer’s disease (AD) using a system network level based in silico approach.
Study results showed that the compounds in ATR are highly connected to AD-related signaling pathways, biological processes, and organs.
These findings were confirmed by compound-target network, target-organ location network, gene ontology analysis, and KEGG pathway enrichment analysis.
Most compounds in ATR have been reported to have antifibrillar amyloid plaques, anti-tau phosphorylation, and anti-inflammatory effects.
Our results indicated that compounds in ATR interact with multiple targets in a synergetic way.
Furthermore, the mRNA expressions of genes targeted by ATR are elevated significantly in heart, brain, and liver.
Our results suggest that the anti-inflammatory and immune system enhancing effects of ATR might contribute to its major therapeutic effects on Alzheimer’s disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Song, Zhenyan& Yin, Fang& Xiang, Biao& Lan, Bin& Cheng, Shaowu. 2018. Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1155458
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Song, Zhenyan…[et al.]. Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1155458
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Song, Zhenyan& Yin, Fang& Xiang, Biao& Lan, Bin& Cheng, Shaowu. Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1155458
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155458
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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