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Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease
Joint Authors
Song, Zhenyan
Yin, Fang
Xiang, Biao
Lan, Bin
Cheng, Shaowu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-27
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
In traditional Chinese medicine (TCM), Acori Tatarinowii Rhizoma (ATR) is widely used to treat memory and cognition dysfunction.
This study aimed to confirm evidence regarding the potential therapeutic effect of ATR on Alzheimer’s disease (AD) using a system network level based in silico approach.
Study results showed that the compounds in ATR are highly connected to AD-related signaling pathways, biological processes, and organs.
These findings were confirmed by compound-target network, target-organ location network, gene ontology analysis, and KEGG pathway enrichment analysis.
Most compounds in ATR have been reported to have antifibrillar amyloid plaques, anti-tau phosphorylation, and anti-inflammatory effects.
Our results indicated that compounds in ATR interact with multiple targets in a synergetic way.
Furthermore, the mRNA expressions of genes targeted by ATR are elevated significantly in heart, brain, and liver.
Our results suggest that the anti-inflammatory and immune system enhancing effects of ATR might contribute to its major therapeutic effects on Alzheimer’s disease.
American Psychological Association (APA)
Song, Zhenyan& Yin, Fang& Xiang, Biao& Lan, Bin& Cheng, Shaowu. 2018. Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1155458
Modern Language Association (MLA)
Song, Zhenyan…[et al.]. Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1155458
American Medical Association (AMA)
Song, Zhenyan& Yin, Fang& Xiang, Biao& Lan, Bin& Cheng, Shaowu. Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1155458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155458