Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats
المؤلفون المشاركون
Wang, Yang
Xiong, Xin-Gui
Wu, Dan
Zhu, Hao
Liang, Qing-hua
Zhang, Zhi-hui
Sun, Mei-juan
Lu, Xun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
In China, Oldenlandia diffusa (OD) is a natural herb that is widely used and has been proven to be effective in the treatment of rheumatoid arthritis (RA).
This study aimed to preliminarily reveal the mechanism by which OD exerts its beneficial effect.
Methods.
Ultra-performance liquid chromatography photodiode array was applied to identify the absorbable compounds in the plasma of collagen-induced arthritis (CIA) model rats.
After 2 weeks, an OD decoction or the identified absorbable compound was administered to CIA rats.
Morphology, X-ray images of the joints, pathological images, arthritis index, and cytokine (TNF-α and IL-6) levels were evaluated.
Results.
p-Coumaric acid (p-CA) was identified as the absorbed compound in plasma.
After administration of p-CA solution or the OD decoction, symptoms in the treated rats were alleviated as compared to the untreated model rats, and inflammatory cell infiltration was suppressed.
The arthritis index and serum levels of TNF-α and IL-6 were decreased as compared to the control group.
Conclusions.
OD may exert its anti-inflammatory effect on RA via its active ingredient, p-CA.
This information sheds light on the mechanism by which OD exerts its anti-inflammatory effort in RA and forms the basis for further development of therapeutic agents for RA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Hao& Liang, Qing-hua& Xiong, Xin-Gui& Wang, Yang& Zhang, Zhi-hui& Sun, Mei-juan…[et al.]. 2018. Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155464
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Hao…[et al.]. Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155464
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Hao& Liang, Qing-hua& Xiong, Xin-Gui& Wang, Yang& Zhang, Zhi-hui& Sun, Mei-juan…[et al.]. Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155464
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155464
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر