Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats
Joint Authors
Wang, Yang
Xiong, Xin-Gui
Wu, Dan
Zhu, Hao
Liang, Qing-hua
Zhang, Zhi-hui
Sun, Mei-juan
Lu, Xun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objectives.
In China, Oldenlandia diffusa (OD) is a natural herb that is widely used and has been proven to be effective in the treatment of rheumatoid arthritis (RA).
This study aimed to preliminarily reveal the mechanism by which OD exerts its beneficial effect.
Methods.
Ultra-performance liquid chromatography photodiode array was applied to identify the absorbable compounds in the plasma of collagen-induced arthritis (CIA) model rats.
After 2 weeks, an OD decoction or the identified absorbable compound was administered to CIA rats.
Morphology, X-ray images of the joints, pathological images, arthritis index, and cytokine (TNF-α and IL-6) levels were evaluated.
Results.
p-Coumaric acid (p-CA) was identified as the absorbed compound in plasma.
After administration of p-CA solution or the OD decoction, symptoms in the treated rats were alleviated as compared to the untreated model rats, and inflammatory cell infiltration was suppressed.
The arthritis index and serum levels of TNF-α and IL-6 were decreased as compared to the control group.
Conclusions.
OD may exert its anti-inflammatory effect on RA via its active ingredient, p-CA.
This information sheds light on the mechanism by which OD exerts its anti-inflammatory effort in RA and forms the basis for further development of therapeutic agents for RA.
American Psychological Association (APA)
Zhu, Hao& Liang, Qing-hua& Xiong, Xin-Gui& Wang, Yang& Zhang, Zhi-hui& Sun, Mei-juan…[et al.]. 2018. Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155464
Modern Language Association (MLA)
Zhu, Hao…[et al.]. Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155464
American Medical Association (AMA)
Zhu, Hao& Liang, Qing-hua& Xiong, Xin-Gui& Wang, Yang& Zhang, Zhi-hui& Sun, Mei-juan…[et al.]. Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155464