Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells
المؤلفون المشاركون
Yanwei, Li
Yinli, Yang
Pan, Zhanyu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-02-13
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Antiangiogenic therapy is vital in nasopharyngeal carcinoma (NPC) treatment.
NPC01 has already been successfully used in treating patients with NPC in clinical practice and exerted an excellent antiangiogenetic effect.
However, the potential molecular mechanism underlying the antitumor effect of NPC01 has not been well explored.
The present study demonstrated that NPC01 could significantly inhibit cell proliferation and induce cell apoptosis in a dose-dependent manner in human NPC cell lines.
Furthermore, NPC01 exerted antiproliferative and antiangiogenic effects in NPC xenograft mice.
Moreover, the study showed that NPC01 could significantly decrease the expression of angiogenesis-associated factors including hypoxia-inducible factor-1α and vascular endothelial growth factor.
Additionally, the decreased expression of these angiogenesis-associated factors could be due to the inhibition of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway (PI3K/Akt/mTOR).
In conclusion, the results proposed that NPC01 could exert its antitumor effect by suppressing the PI3K/Akt/mTOR signaling pathway.
Further studies are warranted to elucidate the molecular mechanism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yanwei, Li& Yinli, Yang& Pan, Zhanyu. 2018. Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yanwei, Li…[et al.]. Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yanwei, Li& Yinli, Yang& Pan, Zhanyu. Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر