Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells
Joint Authors
Yanwei, Li
Yinli, Yang
Pan, Zhanyu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Antiangiogenic therapy is vital in nasopharyngeal carcinoma (NPC) treatment.
NPC01 has already been successfully used in treating patients with NPC in clinical practice and exerted an excellent antiangiogenetic effect.
However, the potential molecular mechanism underlying the antitumor effect of NPC01 has not been well explored.
The present study demonstrated that NPC01 could significantly inhibit cell proliferation and induce cell apoptosis in a dose-dependent manner in human NPC cell lines.
Furthermore, NPC01 exerted antiproliferative and antiangiogenic effects in NPC xenograft mice.
Moreover, the study showed that NPC01 could significantly decrease the expression of angiogenesis-associated factors including hypoxia-inducible factor-1α and vascular endothelial growth factor.
Additionally, the decreased expression of these angiogenesis-associated factors could be due to the inhibition of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway (PI3K/Akt/mTOR).
In conclusion, the results proposed that NPC01 could exert its antitumor effect by suppressing the PI3K/Akt/mTOR signaling pathway.
Further studies are warranted to elucidate the molecular mechanism.
American Psychological Association (APA)
Yanwei, Li& Yinli, Yang& Pan, Zhanyu. 2018. Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155478
Modern Language Association (MLA)
Yanwei, Li…[et al.]. Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1155478
American Medical Association (AMA)
Yanwei, Li& Yinli, Yang& Pan, Zhanyu. Traditional Herbal Formula NPC01 Exerts Antiangiogenic Effects through Inhibiting the PI3KAktmTOR Signaling Pathway in Nasopharyngeal Carcinoma Cells. Evidence-Based Complementary and Alternative Medicine. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1155478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155478