Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice

المؤلفون المشاركون

Zhang, Jin-Jie
Shi, Xiao-Rong
Lv, Wen-Wen
Zhou, Xiao-Long
Sun, Ying-Dong
Li, Bao-Yuan
Hu, Xiao-Long

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2020-02-28

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Oxidative stress (OS) is a crucial factor influencing the development of Parkinson’s disease (PD).

Here we first reported that Lindleyin (Lin), one of the major components of rhubarb, possessed neuroprotective effects against H2O2-induced SH-SY5Y cell injury and MPTP-induced PD of C57BL/6 mice.

The results showed that Lin can decrease cell death and apoptotic rate induced by H2O2 through inhibiting mitochondrial apoptotic pathway and increasing the activities of SOD, GSH-Px, and CAT as well as decreasing the level of MDA.

In addition, in vivo studies showed that oral administration of Lin (5 or 20 mg/kg) showed significant change in motor function deficits, antioxidant enzyme activities, apoptotic pathway, and tyrosine hydroxylase expression.

Our results reveal that Lin might be a promising anti-PD agent by reducing OS and apoptosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Jin-Jie& Shi, Xiao-Rong& Lv, Wen-Wen& Zhou, Xiao-Long& Sun, Ying-Dong& Li, Bao-Yuan…[et al.]. 2020. Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155484

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Jin-Jie…[et al.]. Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155484

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Jin-Jie& Shi, Xiao-Rong& Lv, Wen-Wen& Zhou, Xiao-Long& Sun, Ying-Dong& Li, Bao-Yuan…[et al.]. Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155484

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1155484