Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice
Joint Authors
Zhang, Jin-Jie
Shi, Xiao-Rong
Lv, Wen-Wen
Zhou, Xiao-Long
Sun, Ying-Dong
Li, Bao-Yuan
Hu, Xiao-Long
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Oxidative stress (OS) is a crucial factor influencing the development of Parkinson’s disease (PD).
Here we first reported that Lindleyin (Lin), one of the major components of rhubarb, possessed neuroprotective effects against H2O2-induced SH-SY5Y cell injury and MPTP-induced PD of C57BL/6 mice.
The results showed that Lin can decrease cell death and apoptotic rate induced by H2O2 through inhibiting mitochondrial apoptotic pathway and increasing the activities of SOD, GSH-Px, and CAT as well as decreasing the level of MDA.
In addition, in vivo studies showed that oral administration of Lin (5 or 20 mg/kg) showed significant change in motor function deficits, antioxidant enzyme activities, apoptotic pathway, and tyrosine hydroxylase expression.
Our results reveal that Lin might be a promising anti-PD agent by reducing OS and apoptosis.
American Psychological Association (APA)
Zhang, Jin-Jie& Shi, Xiao-Rong& Lv, Wen-Wen& Zhou, Xiao-Long& Sun, Ying-Dong& Li, Bao-Yuan…[et al.]. 2020. Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155484
Modern Language Association (MLA)
Zhang, Jin-Jie…[et al.]. Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1155484
American Medical Association (AMA)
Zhang, Jin-Jie& Shi, Xiao-Rong& Lv, Wen-Wen& Zhou, Xiao-Long& Sun, Ying-Dong& Li, Bao-Yuan…[et al.]. Neuroprotective Effects of Lindleyin on Hydrogen Peroxide-Induced Cell Injury and MPTP-Induced Parkinson’s Disease in C57BL6 Mice. Evidence-Based Complementary and Alternative Medicine. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1155484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1155484