The Challenge of Treatment in Potential Celiac Disease
المؤلفون المشاركون
Cucchiara, Salvatore
Oliva, Salvatore
Valitutti, Francesco
Trovato, Chiara Maria
Montuori, Monica
Leter, Beatrice
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-10-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Potential celiac disease (PCD) is defined by the presence of positive serum antibodies, HLA-DQ2/DQ8 haplotypes, and a normal small intestinal mucosa (Marsh grade 0-1).
This condition occurs in one-fifth of celiac disease (CD) patients and usually represents a clinical challenge.
We reviewed genetic, histologic, and clinical features of this specific condition by performing a systematic search on MEDLINE, Embase, and Scholar database.
Accordingly, we identified different genetic features in patients with PCD compared to the classical forms.
Frequently, signs of inflammation (deposits of immunoglobulin A (IgA) and/or increased number of intraepithelial lymphocytes) can be clearly identify in the mucosa of PCD patients after an accurate histological assessment.
Finally, the main challenge is represented by the treatment: the gluten-free diet should be considered only in the presence of gluten-dependent symptoms in both children and adults.
What is known: (i) potential celiac disease (PCD) occurs in one-fifth of all celiac diseases (CD), and (ii) despite the absence of classical lesions, clear signs of inflammation are often detectable.
What is new: (i) patients with PCD show different genetic features, and (ii) the presence of gluten-dependent symptoms is the main determinant to initiate the gluten-free diet, after a complete diagnostic work-up.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Trovato, Chiara Maria& Montuori, Monica& Valitutti, Francesco& Leter, Beatrice& Cucchiara, Salvatore& Oliva, Salvatore. 2019. The Challenge of Treatment in Potential Celiac Disease. Gastroenterology Research and Practice،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1155540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Trovato, Chiara Maria…[et al.]. The Challenge of Treatment in Potential Celiac Disease. Gastroenterology Research and Practice No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1155540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Trovato, Chiara Maria& Montuori, Monica& Valitutti, Francesco& Leter, Beatrice& Cucchiara, Salvatore& Oliva, Salvatore. The Challenge of Treatment in Potential Celiac Disease. Gastroenterology Research and Practice. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1155540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1155540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر